Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900105 | 0.83 | EGFR (0.39) | KMT2AMEN1GAAMDM2ALDH1A1 | |
| SCHEMBL7899177 | 0.78 | CYP2C9 (0.43) | CYP2C9CYP2C19KMT2AMEN1GAA | |
| SCHEMBL15676054 | 0.73 | GRM5 (0.45) | CYP2C9CYP2C19ALDH1A1GRM5KDM4E | |
| SCHEMBL19795867 | 0.73 | GRM5 (0.45) | CYP2C9CYP2C19ALDH1A1GRM5KDM4E | |
| SCHEMBL5136321 | 0.72 | LMNA (0.40) | CYP2C9CYP2C19KMT2AMEN1MDM2 | |
| SCHEMBL14437759 | 0.72 | LMNA (0.40) | CYP2C9CYP2C19KMT2AMEN1MDM2 | |
| SCHEMBL30695642 | 0.71 | MDM2 (0.43) | CYP2C9CYP2C19KMT2AMEN1GAA | |
| SCHEMBL15699098 | 0.68 | GRM5 (0.44) | KMT2AMEN1GRM5 | |
| SCHEMBL15676299 | 0.68 | GRM5 (0.44) | KMT2AMEN1GRM5 | |
| SCHEMBL19061962 | 0.68 | GRM5 (0.44) | KMT2AMEN1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |