Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAPDH | P04406 | 1/20 | 0.36 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7527637 | 0.86 | GRM5 (0.46) | GRM5POLBTDP1HSPA1APTPN7 | |
| SCHEMBL9321602 | 0.86 | GRM5 (0.46) | GRM5POLBTDP1HSPA1APTPN7 | |
| SCHEMBL6509232 | 0.80 | EDNRA (0.47) | KMT2AMEN1GRM5POLBHSPA1A | |
| SCHEMBL7900098 | 0.78 | CYP2C9 (0.39) | CYP2C9CYP2C19KMT2AMEN1HDAC4 | |
| SCHEMBL30695642 | 0.76 | MDM2 (0.43) | CYP2C9CYP2C19KMT2AMEN1GRM5 | |
| SCHEMBL11430937 | 0.75 | ALDH1A1 (0.47) | GAASMN1; SMN2KDM4ENPSR1ALDH1A1 | |
| SCHEMBL9212615 | 0.74 | KDM4E (0.41) | KMT2AMEN1POLBGAAKDM4E | |
| SCHEMBL15676211 | 0.73 | MAPT (0.40) | KMT2AMEN1GAAKDM4ECYP2D6 | |
| SCHEMBL11546959 | 0.72 | CYP2D6 (0.46) | KMT2AGRM5POLBTDP1KDM4E | |
| SCHEMBL7534121 | 0.72 | GRM5 (0.44) | GRM5POLBKDM4ECYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |