SCHEMBL7900180

SCHEMBL7900180

CN(C(=O)n1cnc(-c2cccc(-c3ccc(Cl)nc3)c2)c1)C12CC3CC4CC(C1)C4(C3)C2

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.36
CES2 O00748 1/20 0.36
FYN P06241 1/20 0.30
TYRO3 Q06418 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL424683 0.86 FAAH (0.41) FAAHCES2FYNTYRO3
SCHEMBL425847 0.77 FAAH (0.40) FAAHCES2TYRO3
SCHEMBL427570 0.75 HSD17B1 (0.41) FAAHCES2FYN
SCHEMBL427545 0.75 FAAH (0.47) FAAHCES2
SCHEMBL427917 0.75 TP53 (0.53) FAAHCES2
SCHEMBL425928 0.74 TSHR (0.43) FAAHCES2TYRO3
SCHEMBL427564 0.74 FAAH (0.40) FAAHCES2
SCHEMBL425848 0.73 FAAH (0.41) FAAHCES2FYN
SCHEMBL427136 0.73 USP2 (0.44) FAAHCES2FYN
SCHEMBL424670 0.72 FAAH (0.39) FAAHCES2FYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010074588-A2 PHARMACEUTICAL COMPOUNDS BIAL - PORTELA & Cª, S.A. (PT) 2010-07-01 WO disclosed