Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.48 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.48 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | AMD1 | P17707 | 2/20 | 0.38 |
| ▸ | TYMP | P19971 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889979 | 0.83 | PI4KA (0.52) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL1798669 | 0.83 | PI4KA (0.52) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL5672711 | 0.78 | PI4KA (0.51) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL1757060 | 0.78 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL91054 | 0.78 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL7735012 | 0.78 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395424 | 0.78 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL12629188 | 0.78 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL21882960 | 0.78 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL1795588 | 0.78 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37045-E1 | N-6 substituted-5′-(N-substituted carboxamide)adenosines as cardiac vasodilator and antihypertensive agents | DISCOVERY THERAPEUTICS, INC. | 2001-02-06 | — | — | US | disclosed |
| US-5310731-A | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents | WHITBY RESEARCH, INC. (US) | 1994-05-10 | — | — | US | disclosed |
| EP-0191025-B1 | N-6 AND 5'-N SUBSTITUTED CARBOXAMIDOADENOSINE DERIVATIVES AS CARDIAC VASODILATORS AND ANTIHYPERTENSIVE AGENTS, AND PROCESS FOR MAKING SAID COMPOUNDS | Whitby Research Incorporated (US) | 1990-03-07 | — | — | EP | disclosed |
| EP-0191025-A1 | N-6 AND 5'-N SUBSTITUTED CARBOXAMIDOADENOSINE DERIVATIVES AS CARDIAC VASODILATORS AND ANTIHYPERTENSIVE AGENTS, AND PROCESS FOR MAKING SAID COMPOUNDS. | NELSON RES & DEV (US) | 1986-08-20 | — | — | EP | disclosed |
| WO-1986000310-A1 | N-6 AND 5'-N SUBSTITUTED CARBOXAMIDOADENOSINE DERIVATIVES AS CARDIAC VASODILATORS AND ANTIHYPERTENSIVE AGENTS, AND PROCESS FOR MAKING SAID COMPOUNDS | NELSON RESEARCH AND DEVELOPMENT COMPANY (US) | 1986-01-16 | — | — | WO | disclosed |