Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904170 | 1.00 | EGFR (0.49) | EGFRNPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL13874386 | 0.81 | NPC1 (0.49) | NPC1RAB9APKMSMN1; SMN2FDPS | |
| SCHEMBL7902105 | 0.81 | SMN1; SMN2 (0.51) | NPC1RAB9APKMSMN1; SMN2FDPS | |
| SCHEMBL7904169 | 0.81 | SMN1; SMN2 (0.51) | NPC1RAB9APKMSMN1; SMN2FDPS | |
| SCHEMBL26626445 | 0.80 | EGFR (0.41) | EGFRCYP1A2HCAR3HCAR2 | |
| SCHEMBL30716707 | 0.80 | EGFR (0.41) | EGFRCYP1A2HCAR3HCAR2 | |
| SCHEMBL3937332 | 0.80 | EGFR (0.41) | EGFRCYP1A2HCAR3HCAR2 | |
| SCHEMBL7897990 | 0.80 | EGFR (0.41) | EGFRCYP1A2HCAR3HCAR2 | |
| SCHEMBL26802158 | 0.78 | HCAR3 (0.43) | EGFRNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL3848170 | 0.78 | NPC1 (0.46) | NPC1RAB9APKMSMN1; SMN2FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |