Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904169 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL183600 | 0.86 | HCAR3 (0.57) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL13874386 | 0.83 | NPC1 (0.49) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL7900361 | 0.81 | EGFR (0.49) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL7904170 | 0.81 | EGFR (0.49) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL13115714 | 0.81 | ALDH1A1 (0.53) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL30716722 | 0.79 | KDM4E (0.51) | SMN1; SMN2KDM4EALDH1A1MAPTHCAR3 | |
| SCHEMBL22000883 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL31362141 | 0.79 | KDM4E (0.51) | SMN1; SMN2KDM4EALDH1A1MAPTHCAR3 | |
| SCHEMBL3848170 | 0.79 | NPC1 (0.46) | SMN1; SMN2KDM4EALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |