SCHEMBL7900708

SCHEMBL7900708

Cc1ccc(C)c([C@@H](Cl)CCC(=O)O)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.49
MEN1 O00255 1/20 0.49
TSHR P16473 1/20 0.46
FFAR1 O14842 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.38
LMNA P02545 1/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
POLB P06746 2/20 0.38
KDM4E B2RXH2 1/20 0.38
HSD17B10 Q99714 1/20 0.38
SRC P12931 1/20 0.37
GAA P10253 2/20 0.37
TP53 P04637 1/20 0.37
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7900705 1.00 KMT2A (0.49) KMT2AMEN1TSHRFFAR1SMN1; SMN2
SCHEMBL7813526 0.82 KMT2A (0.50) KMT2AMEN1TSHRFFAR1SMN1; SMN2
SCHEMBL28396453 0.81 KMT2A (0.49) KMT2AMEN1TSHRFFAR1L3MBTL1
SCHEMBL28396451 0.81 KMT2A (0.49) KMT2AMEN1TSHRFFAR1L3MBTL1
SCHEMBL7907662 0.80 ALDH1A1 (0.42) TSHRPOLBKDM4EHSD17B10GAA
SCHEMBL7907656 0.80 ALDH1A1 (0.42) TSHRPOLBKDM4EHSD17B10GAA
SCHEMBL7911091 0.80 ALDH1A1 (0.42) TSHRPOLBKDM4EHSD17B10GAA
Hydrochloric Acid SCHEMBL18077188 0.79 KMT2A (0.47) KMT2AMEN1TSHRFFAR1L3MBTL1
SCHEMBL11822023 0.76 KMT2A (0.47) KMT2AFFAR1SMN1; SMN2LMNAL3MBTL1
SCHEMBL5457124 0.75 TSHR (0.51) KMT2AMEN1TSHRFFAR1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211234-B1 BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID RHONE-POULENC RORER LIMITED (GB) 2001-04-03 US disclosed
EP-0728128-B1 SUBSTITUTED PHENYL COMPOUNDS RHONE POULENC RORER LTD (GB) 1998-09-16 EP disclosed
EP-0728128-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1996-08-28 EP disclosed
WO-1995013262-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1995-05-18 WO disclosed