Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.56 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4102372 | 1.00 | PIK3CD (0.56) | PIK3CDGPR119USP30PIK3CAPIK3CB | |
| SCHEMBL4714125 | 0.92 | GPR119 (0.62) | GPR119 | |
| SCHEMBL2995903 | 0.89 | GPR119 (0.51) | PIK3CDGPR119USP30 | |
| SCHEMBL31108147 | 0.86 | HMOX1 (0.57) | PIK3CDGPR119PIK3CAPIK3CBPIK3CG | |
| SCHEMBL31108144 | 0.86 | HMOX1 (0.57) | PIK3CDGPR119PIK3CAPIK3CBPIK3CG | |
| SCHEMBL23842628 | 0.86 | PIK3CD (0.53) | PIK3CDGPR119PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2536876 | 0.86 | HMOX1 (0.57) | PIK3CDGPR119PIK3CAPIK3CBPIK3CG | |
| SCHEMBL22055497 | 0.84 | PIK3CD (0.52) | PIK3CDGPR119PIK3CAPIK3CBPIK3CG | |
| SCHEMBL30044209 | 0.83 | PIK3CD (0.56) | PIK3CDGPR119PIK3CAPIK3CBPIK3CG | |
| SCHEMBL23608571 | 0.83 | PIK3CD (0.56) | PIK3CDGPR119PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PFIZER INC. (US) | 2014-03-27 | — | — | US | disclosed |
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PFIZER INC. (US) | 2014-03-27 | — | — | US | disclosed |
| EP-2389382-B1 | Amino-heterocyclic compounds used as pde9 inhibitors | PFIZER (US) | 2013-06-05 | — | — | EP | disclosed |
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PFIZER INC. | 2012-12-27 | — | — | US | disclosed |
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PFIZER INC. | 2012-12-27 | — | — | US | disclosed |
| US-8278295-B2 | Amino-heterocyclic compounds | PFIZER INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278295-B2 | Amino-heterocyclic compounds | PFIZER INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2010-07-29 | — | — | US | disclosed |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PFIZER INC. | 2010-07-29 | — | — | US | disclosed |
| WO-2010084438-A1 | AMINO-HETEROCYCLIC COMPOUNDS USED AS PDE9 INHIBITORS | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329777-A1 | Amino-Heterocyclic Compounds | PDE9A, PDE2A, PDE10A | PIK3CD 597/4885GPR119 95/4885USP30 1948/4885 |
| US-20100190771-A1 | AMINO-HETEROCYCLIC COMPOUNDS | PDE9A, PDE2A, PDE10A | PIK3CD 597/4885GPR119 95/4885USP30 1948/4885 |
| US-20140088081-A1 | Amino-Heterocyclic Compounds | PDE9A, PDE2A, PDE10A | PIK3CD 597/4885GPR119 95/4885USP30 1948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.