Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5479059 | 0.78 | GUSB (0.42) | CYP3A4CYP2D6KMT2A | |
| SCHEMBL6915415 | 0.76 | DYRK1A (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12516813 | 0.76 | DYRK1A (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27971322 | 0.76 | ALDH1A1 (0.56) | DYRK1AKITKMT2A | |
| SCHEMBL7896922 | 0.74 | DYRK1A (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29637091 | 0.74 | DYRK1A (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1492639 | 0.74 | DYRK1A (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11919644 | 0.71 | WNT3A (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2350999 | 0.71 | DYRK1A (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2489888 | 0.70 | ALDH1A1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071741-A1 | TRIAZOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME CORP. (US) | 2010-06-24 | — | — | WO | disclosed |