Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | PDE2A | O00408 | 1/20 | 0.59 |
| ▸ | PDE6D | O43924 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | PDE9A | O76083 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | PDE6A | P16499 | 1/20 | 0.59 |
| ▸ | PDE6G | P18545 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
| ▸ | PDE6B | P35913 | 1/20 | 0.59 |
| ▸ | PDE6C | P51160 | 1/20 | 0.59 |
| ▸ | PDE1A | P54750 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7159216 | 0.87 | PDE5A (0.66) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7901175 | 0.86 | PDE5A (0.61) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7159205 | 0.84 | PDE5A (0.60) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7165152 | 0.83 | PDE5A (0.57) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7164458 | 0.82 | GUSB (0.81) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7899533 | 0.82 | PDE5A (0.57) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL3840295 | 0.80 | PDE5A (0.57) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7901174 | 0.80 | PDE5A (0.56) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7901172 | 0.80 | PDE5A (0.56) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL149241 | 0.79 | PDE5A (0.72) | PDE5AKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187779-B1 | ADMINISTERING ANTITUMOR AGENTS TO TREAT COLON CANCER | CELL PATHWAYS, INC. | 2001-02-13 | — | — | US | disclosed |
| US-5721238-A | ANTIINFLAMMATORY AGENTS, CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-02-24 | — | — | US | disclosed |
| EP-0722937-A1 | 2,8-Disubstituted quinazolinone | BAYER AG (DE) | 1996-07-24 | — | — | EP | disclosed |