SCHEMBL7901547

SCHEMBL7901547

C[C@H](NC(=O)CCN)C(=O)OCCCc1ccc(-c2c(C#N)c(SCc3csc(-c4ccc(Cl)cc4)n3)nc(N3CCC3)c2C#N)cc1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 20/20 0.48
SLC6A3 Q01959 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3736320 0.93 ADORA1 (0.56) ADORA1SLC6A3
SCHEMBL7894255 0.92 ADORA1 (0.56) ADORA1SLC6A3
Hydrochloric Acid SCHEMBL3726362 0.91 ADORA1 (0.56) ADORA1SLC6A3
SCHEMBL7901799 0.89 ADORA1 (0.55) ADORA1SLC6A3
SCHEMBL7899855 0.89 ADORA1 (0.53) ADORA1SLC6A3
SCHEMBL7898605 0.89 ADORA1 (0.43) ADORA1SLC6A3
Trifluoroacetic Acid SCHEMBL3737918 0.88 ADORA1 (0.52) ADORA1SLC6A3
SCHEMBL7904181 0.87 ADORA1 (0.51) ADORA1SLC6A3
SCHEMBL13227875 0.86 ADORA1 (0.52) ADORA1SLC6A3
SCHEMBL13260916 0.86 ADORA1 (0.50) ADORA1SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010086101-A1 ALKYLAMINE-SUBSTITUTED DICYANOPYRIDINE AND AMINO ACID ESTER PRODRUGS THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2010-08-05 WO disclosed