Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682241 | 0.82 | MAPT (0.50) | SMN1; SMN2HTTRAB9ANPC1MAPT | |
| SCHEMBL4682237 | 0.82 | MAPT (0.50) | SMN1; SMN2HTTRAB9ANPC1MAPT | |
| SCHEMBL19773941 | 0.78 | HPGD (0.42) | SMN1; SMN2HTTRAB9ANPC1MAPT | |
| SCHEMBL17237947 | 0.76 | HPGD (0.41) | SMN1; SMN2HTTRAB9ANPC1MAPT | |
| SCHEMBL19774044 | 0.71 | POLB (0.34) | POLB | |
| SCHEMBL4682243 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTRAB9ANPC1MAPT | |
| SCHEMBL17237896 | 0.70 | NPC1 (0.46) | HTTRAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL17238079 | 0.70 | RAB9A (0.46) | SMN1; SMN2HTTRAB9ANPC1MAPT | |
| SCHEMBL8620720 | 0.69 | MEN1 (0.42) | SMN1; SMN2HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL8620709 | 0.69 | MEN1 (0.42) | SMN1; SMN2HTTRAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197797-B1 | ANTICANCER AGENTS; SKIN DISORDERS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-03-06 | — | — | US | disclosed |
| US-6121297-A | SUCH AS N-CYANO-N'-(11-PHENOXYUNDECYL)-N?-4-PYRIDYLGUANIDINE; N-CYANO-N'-(10-PHENOXYDECYL)-N?-4-PYRIDYLGUANIDINE; N-CYANO-N'-(9-PHENOXYNONYL)-N?-4-PYRIDYLGUANIDINE; OR THEIR SALTS; TREATING SKIN CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2000-09-19 | — | — | US | disclosed |