Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620712 | 1.00 | MEN1 (0.42) | MEN1KMT2AP2RX7KCNJ11SMN1; SMN2 | |
| SCHEMBL8620709 | 1.00 | MEN1 (0.42) | MEN1KMT2AP2RX7KCNJ11SMN1; SMN2 | |
| SCHEMBL7359995 | 0.88 | P2RX7 (0.45) | P2RX7TRPV1KCNA5ROCK2ROCK1 | |
| SCHEMBL8619959 | 0.88 | P2RX7 (0.45) | P2RX7TRPV1KCNA5ROCK2ROCK1 | |
| SCHEMBL8618718 | 0.88 | P2RX7 (0.45) | P2RX7TRPV1KCNA5ROCK2ROCK1 | |
| SCHEMBL8775014 | 0.78 | KMT2A (0.47) | MEN1KMT2AKCNJ11SMN1; SMN2NPC1 | |
| SCHEMBL13949284 | 0.78 | KMT2A (0.47) | MEN1KMT2AKCNJ11SMN1; SMN2NPC1 | |
| SCHEMBL7356810 | 0.78 | KMT2A (0.47) | MEN1KMT2AKCNJ11SMN1; SMN2NPC1 | |
| SCHEMBL4258463 | 0.78 | KMT2A (0.47) | MEN1KMT2AKCNJ11SMN1; SMN2NPC1 | |
| SCHEMBL7356807 | 0.78 | KMT2A (0.47) | MEN1KMT2AKCNJ11SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | claimed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | claimed |
| EP-0741708-B1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | UPJOHN CO (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5668157-A | Cyanoguanidines as K-channel blockers | PHARMACIA & UPJOHN COMPANY (US) | 1997-09-16 | — | — | US | disclosed |