Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2115084 | 0.77 | POLB (0.33) | POLBCYP1A2CYP3A4GAACYP2D6 | |
| Fluoride Ion SCHEMBL7641578 | 0.74 | POLB (0.33) | POLBCYP1A2CYP3A4GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL4467996 | 0.71 | POLB (0.31) | POLB | |
| Hydrochloric Acid SCHEMBL816513 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL7782823 | 0.67 | POLB (0.42) | POLBCYP1A2CYP3A4GAACYP2D6 | |
| Hydrochloric Acid SCHEMBL1235501 | 0.67 | POLB (0.32) | POLB | |
| Hydrochloric Acid SCHEMBL16424528 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL9069259 | 0.66 | POLB (0.31) | POLB | |
| Hydrochloric Acid SCHEMBL4468693 | 0.66 | POLB (0.31) | POLB | |
| Hydrochloric Acid SCHEMBL7902043 | 0.66 | POLB (0.31) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197902-B1 | Syndio-isoblock polymer and process for its preparation | TARGOR GMBH (DE) | 2001-03-06 | — | — | US | claimed |
| EP-0399347-B1 | Process for preparing a Syndio-isoblockpolymer | HOECHST AG (DE) | 1996-08-14 | — | — | EP | claimed |
| US-6225425-B1 | SUSPENSION OR GAS PHASE POLYMERIZATION OF PROPYLENE OR CYCLIC OLEFIN IN PRESENCE OF CATALYST COMPRISING METALLOCENE AND ALUMINOXANE | TARGOR GMBH (DE) | 2001-05-01 | — | — | US | disclosed |
| US-6197902-B1 | Syndio-isoblock polymer and process for its preparation | TARGOR GMBH (DE) | 2001-03-06 | — | — | US | disclosed |