Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 7/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.30 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
| ▸ | HRH2 | P25021 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902463 | 0.92 | USP30 (0.33) | USP30KLK5AAK1SCN9AITGB3 | |
| SCHEMBL7898296 | 0.91 | CNR2 (0.33) | USP30KLK5RENCYP3A4AAK1 | |
| SCHEMBL7897738 | 0.90 | PADI4 (0.37) | USP30KLK5AAK1SCN9APADI4 | |
| SCHEMBL7889785 | 0.89 | L3MBTL1 (0.32) | USP30KLK5RENCYP3A4AAK1 | |
| SCHEMBL7900607 | 0.89 | L3MBTL1 (0.32) | USP30KLK5RENCYP3A4AAK1 | |
| SCHEMBL7902535 | 0.88 | USP30 (0.32) | USP30KLK5RENCYP3A4AAK1 | |
| SCHEMBL7898919 | 0.85 | USP30 (0.32) | USP30KLK5AAK1SCN9A | |
| SCHEMBL2790479 | 0.84 | ALDH1A1 (0.31) | REN | |
| SCHEMBL2790483 | 0.84 | ALDH1A1 (0.31) | REN | |
| SCHEMBL762754 | 0.83 | HRH1 (0.38) | USP30KLK5CYP3A4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |