Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 16/20 | 0.48 |
| ▸ | CCKBR | P32239 | 1/20 | 0.43 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.42 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460828 | 1.00 | FOLH1 (0.48) | FOLH1CCKBRNAALAD2RIMKLAGAA | |
| SCHEMBL8815091 | 0.93 | NAALAD2 (0.46) | FOLH1NAALAD2GAA | |
| SCHEMBL8723910 | 0.92 | KMT2A (0.42) | FOLH1 | |
| SCHEMBL8722915 | 0.89 | FOLH1 (0.48) | FOLH1CCKBRNAALAD2RIMKLAGAA | |
| SCHEMBL7906574 | 0.88 | FOLH1 (0.49) | FOLH1CCKBRNAALAD2RIMKLAGAA | |
| SCHEMBL7894806 | 0.88 | FOLH1 (0.49) | FOLH1CCKBRNAALAD2RIMKLAGAA | |
| SCHEMBL7900456 | 0.87 | FOLH1 (0.48) | FOLH1CCKBRNAALAD2RIMKLAGAA | |
| SCHEMBL4458797 | 0.83 | FOLH1 (0.58) | FOLH1CCKBRNAALAD2RIMKLAGAA | |
| SCHEMBL7902186 | 0.83 | FOLH1 (0.58) | FOLH1CCKBRNAALAD2RIMKLAGAA | |
| SCHEMBL28905229 | 0.83 | TYMS (0.53) | FOLH1CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277880-B1 | ANTIBODY DIRECTED ENZYME PRODUG THERAPY | ZENECA LIMITED (GB) | 2001-08-21 | — | — | US | disclosed |
| EP-0651740-B1 | AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS | ZENECA LTD (GB) | 1998-10-21 | — | — | EP | disclosed |