Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 14/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902175 | 0.93 | FOLH1 (0.48) | NAALAD2FOLH1GAA | |
| SCHEMBL4460828 | 0.93 | FOLH1 (0.48) | NAALAD2FOLH1GAA | |
| SCHEMBL8723910 | 0.85 | KMT2A (0.42) | FOLH1FPR2 | |
| SCHEMBL8722915 | 0.83 | FOLH1 (0.48) | NAALAD2FOLH1FPR2GAA | |
| SCHEMBL7894806 | 0.82 | FOLH1 (0.49) | NAALAD2FOLH1FPR2GAA | |
| SCHEMBL7906574 | 0.82 | FOLH1 (0.49) | NAALAD2FOLH1FPR2GAA | |
| SCHEMBL7900456 | 0.81 | FOLH1 (0.48) | NAALAD2FOLH1FPR2GAA | |
| SCHEMBL8812711 | 0.81 | CCKBR (0.51) | FPR2EPHX2 | |
| SCHEMBL8815104 | 0.81 | CCKBR (0.51) | FPR2EPHX2 | |
| SCHEMBL4458797 | 0.78 | FOLH1 (0.58) | NAALAD2FOLH1FPR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5660829-A | DEESTERIFYING COMPOUND TO FORM N-(4(N,N-BIS(2-CHLOROETHYL) AMINO)PHENOXYCARBONYL)-L-GLUTAMIC ACID-GAMMA-(3,5-DICARBOXY)ANILIDE | ZENECA LIMITED (GB) | 1997-08-26 | — | — | US | disclosed |
| US-5405990-A | For use in antibody directed enzyme prodrug therapy; cytotoxic parent nitrogen mustard; antitumor agents | ZENECA LIMITED (GB) | 1995-04-11 | — | — | US | disclosed |