Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.67 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.67 |
| ▸ | MTOR | P42345 | 5/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
| ▸ | JAK1 | P23458 | 1/20 | 0.67 |
| ▸ | JAK3 | P52333 | 1/20 | 0.67 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902204 | 0.84 | PIK3CA (0.76) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL7894820 | 0.81 | PIK3CA (0.71) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| Vs-5584 SCHEMBL539098 | 0.81 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| Vs-5584 SCHEMBL29376859 | 0.81 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL7900675 | 0.78 | PIK3CA (0.61) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL539256 | 0.78 | PIK3CA (0.78) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL3791135 | 0.77 | PIK3CA (0.77) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL7908617 | 0.77 | PIK3CA (0.76) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL7895963 | 0.77 | PIK3CA (0.76) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL7902199 | 0.76 | PIK3CA (0.65) | PIK3CAPIK3R1MTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114494-A1 | 8-SUBSTITUTED-2-MORPHOLINO PURINES FOR USE AS PI3K AND/OR MTOR INHIBITORS IN THE TREATMENT OF PROLIFERATIVE DISORDERS | S*BIO PTE LTD (SG) | 2010-10-07 | — | — | WO | disclosed |