Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NNMT | P40261 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24796780 | 0.89 | ALDH1A1 (0.49) | POLBTDP1NNMTNPSR1ALDH1A1 | |
| SCHEMBL23667574 | 0.86 | POLB (0.46) | POLBTDP1NNMTNPSR1ALDH1A1 | |
| SCHEMBL29153901 | 0.86 | POLB (0.46) | POLBTDP1NNMTNPSR1ALDH1A1 | |
| SCHEMBL23667230 | 0.86 | POLB (0.46) | POLBTDP1NNMTNPSR1ALDH1A1 | |
| SCHEMBL23649521 | 0.86 | POLB (0.46) | POLBTDP1NNMTNPSR1ALDH1A1 | |
| SCHEMBL23666910 | 0.82 | POLB (0.43) | POLBTDP1NNMTNPSR1ALDH1A1 | |
| SCHEMBL11605385 | 0.81 | TDP1 (0.71) | POLBTDP1NNMTALDH1A1KDM4E | |
| SCHEMBL21041119 | 0.81 | NNMT (0.69) | POLBTDP1NNMTALDH1A1KDM4E | |
| SCHEMBL5583709 | 0.81 | NPSR1 (0.48) | POLBTDP1NNMTNPSR1ALDH1A1 | |
| SCHEMBL25179981 | 0.81 | NPSR1 (0.48) | POLBTDP1NNMTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4363418-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN Pharmaceutica NV (BE) | 2024-05-08 | — | — | EP | disclosed |
| CN-117545757-A | 5-oxo-pyrido [2,3-d ] pyridazin-6 (5H) -ylacetamides | 詹森药业有限公司 | 2024-02-09 | — | — | CN | disclosed |
| WO-2023275230-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2023-01-05 | — | — | WO | disclosed |
| WO-2023275230-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2023-01-05 | — | — | WO | disclosed |
| US-6184229-B1 | 6-pyrrolidin-2-ylpyrindine derivatives, their preparation and application in therapy | SANOFI-SYNTHELABO (FR) | 2001-02-06 | — | — | US | disclosed |