Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903558 | 1.00 | TDP1 (0.39) | TDP1NR4A1MAPTMEN1KMT2A | |
| SCHEMBL7903560 | 1.00 | TDP1 (0.39) | TDP1NR4A1MAPTMEN1KMT2A | |
| SCHEMBL9381500 | 0.78 | TDP1 (0.40) | TDP1NR4A1MAPTMEN1KMT2A | |
| SCHEMBL28095013 | 0.76 | NR4A1 (0.40) | TDP1NR4A1MAPTMEN1KMT2A | |
| SCHEMBL27897234 | 0.75 | TDP1 (0.40) | TDP1NR4A1MAPTMEN1KMT2A | |
| SCHEMBL9539807 | 0.74 | PNMT (0.43) | TDP1ALDH1A1SMN1; SMN2TSHRPDE10A | |
| SCHEMBL27657163 | 0.74 | SMN1; SMN2 (0.45) | TDP1NR4A1MAPTMEN1KMT2A | |
| SCHEMBL9539813 | 0.74 | PNMT (0.43) | TDP1ALDH1A1SMN1; SMN2TSHRPDE10A | |
| SCHEMBL28813906 | 0.74 | NR4A1 (0.39) | TDP1NR4A1MAPTMEN1KMT2A | |
| SCHEMBL6196688 | 0.73 | TSHR (0.41) | TDP1MAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6201119-B1 | 2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-9-AMINE COMPOUNDS USEFUL AS INTERMEDIATES TO ANTIVIRALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-03-13 | — | — | US | disclosed |
| EP-0417840-B1 | Antiviral tetrahydroimidazo [1,4]-benzodiazepines | JANSSEN PHARMACEUTICA NV (BE) | 1994-12-07 | — | — | EP | disclosed |
| US-5371079-A | Administering to inhibit replication of HIV-1 in human cells | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-12-06 | — | — | US | disclosed |
| US-5270464-A | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-14 | — | — | US | disclosed |
| EP-0491751-A1 | ANTIVIRAL TETRAHYDROIMIDAZO 1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-07-01 | — | — | EP | disclosed |
| WO-1991004255-A1 | ANTIVIRAL TETRAHYDROIMIDAZO[1,4]BENZODIAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-04 | — | — | WO | disclosed |