Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539813 | 1.00 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CCHRNB2 | |
| SCHEMBL7903541 | 0.78 | TDP1 (0.40) | PNMTADRA2AADRA2BADRA2CCHRNB2 | |
| SCHEMBL27453650 | 0.78 | PNMT (0.41) | PNMTADRA2AADRA2BADRA2CTSHR | |
| SCHEMBL16269182 | 0.77 | PNMT (0.55) | PNMTADRA2AADRA2BADRA2CCHRNB2 | |
| SCHEMBL9701418 | 0.75 | CHRNB2 (0.40) | PNMTCHRNB2CHRNA4ACHETDP1 | |
| SCHEMBL7480596 | 0.75 | TDP1 (0.38) | PNMTADRA2AADRA2BADRA2CTDP1 | |
| SCHEMBL7903560 | 0.74 | TDP1 (0.39) | CHRNB2CHRNA4TDP1TSHRSMN1; SMN2 | |
| SCHEMBL7903558 | 0.74 | TDP1 (0.39) | CHRNB2CHRNA4TDP1TSHRSMN1; SMN2 | |
| SCHEMBL7903563 | 0.74 | TDP1 (0.39) | CHRNB2CHRNA4TDP1TSHRSMN1; SMN2 | |
| SCHEMBL7391102 | 0.74 | CD44 (0.34) | PNMTADRA2AADRA2BADRA2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0557307-A1 | PROCESS FOR PRODUCING 4,5,6,7-TETRAHYDRO-IMIDAZO-(4,5,LJK) (1,4)-BENZODIAZEPINE-2-(1H)-THIONES AND INTERMEDIATE PRODUCTS | Roche Diagnostics GmbH (DE) | 1993-09-01 | — | — | EP | disclosed |
| WO-1992008706-A1 | PROCESS FOR PRODUCING 4,5,6,7-TETRAHYDRO-IMIDAZO-(4,5,LJK) (1,4)-BENZODIAZEPINE-2-(1H)-THIONES AND INTERMEDIATE PRODUCTS | BOEHRINGER MANNHEIM GMBH (DE) | 1992-05-29 | — | — | WO | disclosed |