Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15761572 | 0.80 | ALDH1A1 (0.49) | HTR2APPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL28845978 | 0.80 | ALDH1A1 (0.49) | HTR2APPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL28845986 | 0.80 | PPARA (0.56) | HTR2APPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL28845985 | 0.80 | PPARA (0.56) | HTR2APPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL12255060 | 0.79 | HTR2A (0.56) | HTR2AALDH1A1SMN1; SMN2MAPTEPHX1 | |
| SCHEMBL4971092 | 0.78 | PPARG (0.41) | HTR2APPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL29935359 | 0.78 | SMN1; SMN2 (0.49) | HTR2APPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL28845980 | 0.78 | SMN1; SMN2 (0.49) | HTR2APPARGPPARAALDH1A1SMN1; SMN2 | |
| SCHEMBL14073621 | 0.77 | HDAC4 (0.42) | EPHX1GAACACNA1BKMT2A | |
| SCHEMBL8288566 | 0.77 | HDAC4 (0.42) | EPHX1GAACACNA1BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230505-A1 | QUINAZOLINE INHIBITORS OF BACE 1 AND METHODS OF USING | PURDUE RESEARCH FOUNDATION (US) | 2011-09-22 | — | — | US | disclosed |
| WO-2010059953-A1 | QUINAZOLINE INHIBITORS OF BACE 1 AND METHODS OF USING | PURDUE RESEARCH FOUNDATION (US) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230505-A1 | QUINAZOLINE INHIBITORS OF BACE 1 AND METHODS OF USING | BACE1, BACE2, PSEN1 | HTR2A 1168/4885PPARG 4044/4885PPARA 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.