Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 6/20 | 0.33 |
| ▸ | TDO2 | P48775 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521003 | 0.76 | KDM4E (0.49) | MEN1KMT2A | |
| SCHEMBL17064513 | 0.74 | GRIN2B (0.35) | IDO1MEN1KMT2A | |
| SCHEMBL13232174 | 0.73 | EPHX1 (0.47) | NPC1TP53RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10021099 | 0.73 | KMT2A (0.43) | METAP1MEN1NPC1TP53TSHR | |
| SCHEMBL317581 | 0.73 | GRIN2B (0.39) | METAP1 | |
| SCHEMBL7903826 | 0.70 | METAP1 (0.34) | METAP1IDO1TDO2MEN1NPC1 | |
| SCHEMBL7897653 | 0.69 | CHRM1 (0.48) | MEN1NPC1TSHRRAB9AKMT2A | |
| SCHEMBL28257255 | 0.68 | LOXL2 (0.45) | NPC1TSHRRAB9A | |
| SCHEMBL10527597 | 0.68 | MAPT (0.40) | MEN1NPC1TP53TSHRRAB9A | |
| SCHEMBL10528119 | 0.67 | CYP19A1 (0.43) | MEN1NPC1TP53TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |