Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521003 | 0.81 | KDM4E (0.49) | CHRM3SLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL281883 | 0.76 | IDO1 (0.48) | ADRB3MEN1LMNAKMT2A | |
| SCHEMBL282798 | 0.76 | IDO1 (0.48) | ADRB3MEN1LMNAKMT2A | |
| SCHEMBL3156406 | 0.76 | IDO1 (0.48) | ADRB3MEN1LMNAKMT2A | |
| SCHEMBL17073486 | 0.75 | RIPK1 (0.39) | CHRM1CHRM3EPHX1 | |
| SCHEMBL31067489 | 0.75 | CPN1 (0.41) | CHRM1CHRM3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL13232174 | 0.75 | EPHX1 (0.47) | EPHX2EPHX1NPC1LMNARAB9A | |
| SCHEMBL17073423 | 0.75 | CPN1 (0.41) | CHRM1CHRM3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL31375638 | 0.74 | OPRM1 (0.44) | EPHX2EPHX1ADRB3SLC6A4SLC6A2 | |
| SCHEMBL26649090 | 0.74 | OPRM1 (0.44) | EPHX2EPHX1ADRB3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |