Benzotriazole

SCHEMBL7904688

CC(C)(C)c1cc(-n2nc3ccccc3n2)c(O)c(C(C)(C)c2ccccc2)c1.c1ccc2[nH]nnc2c1

nearest known ligand 0.36

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	NPC1	O15118	2/20	0.36

▸	RAB9A	P51151	2/20	0.36

▸	LMNA	P02545	2/20	0.33

▸	POLB	P06746	1/20	0.33

▸	CYP1A2	P05177	1/20	0.33

▸	CYP3A4	P08684	1/20	0.33

▸	CYP2C9	P11712	1/20	0.33

▸	TSHR	P16473	1/20	0.33

▸	CYP2C19	P33261	1/20	0.33

▸	TP53	P04637	1/20	0.31

▸	ATM	Q13315	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Benzotriazole SCHEMBL7480928	0.95	NPC1 (0.37)	NPC1RAB9ALMNAPOLBCYP3A4
Benzotriazole SCHEMBL7901441	0.89	NPC1 (0.33)	NPC1RAB9ALMNAPOLB
SCHEMBL1499910	0.88	NPC1 (0.45)	NPC1RAB9ALMNAPOLBCYP1A2
SCHEMBL5510301	0.86	NPC1 (0.41)	NPC1RAB9ALMNAPOLBCYP1A2
Benzotriazole SCHEMBL7895570	0.83	NPC1 (0.33)	NPC1RAB9A
Benzotriazole SCHEMBL3915546	0.82	—	—
SCHEMBL29903	0.82	NPC1 (0.46)	NPC1RAB9ALMNAPOLBCYP3A4
SCHEMBL29354035	0.82	NPC1 (0.46)	NPC1RAB9ALMNAPOLBCYP3A4
Benzotriazole SCHEMBL4615801	0.81	NPC1 (0.36)	NPC1RAB9ALMNAPOLBATM
Benzotriazole SCHEMBL21647390	0.81	NPC1 (0.38)	NPC1RAB9ALMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6268415-B1	POLYMERS AND STABILIZERS FOR ENHANCED STABILITY	CIBA SPECIALTY CHEMICALS CORPORATION	2001-07-31	—	—	US	disclosed