Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 16/20 | 0.55 |
| ▸ | BCHE | P06276 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12059730 | 1.00 | ACHE (0.55) | ACHEBCHEKDM4ECYP2D6ALDH1A1 | |
| SCHEMBL12059733 | 0.87 | ACHE (0.57) | ACHEBCHEKDM4ECYP2D6ALDH1A1 | |
| SCHEMBL12059731 | 0.87 | ACHE (0.57) | ACHEBCHEOPRM1OPRK1 | |
| SCHEMBL12059570 | 0.86 | FAAH (0.49) | ACHEBCHEALDH1A1 | |
| SCHEMBL12059577 | 0.85 | ACHE (0.58) | ACHEBCHEALDH1A1SMN1; SMN2 | |
| SCHEMBL12059567 | 0.85 | FAAH (0.51) | ACHEBCHEALDH1A1 | |
| SCHEMBL12059572 | 0.85 | FAAH (0.51) | ACHEBCHEALDH1A1 | |
| SCHEMBL12059750 | 0.84 | ACHE (0.42) | ACHEBCHEKDM4ECYP2D6ALDH1A1 | |
| SCHEMBL12059749 | 0.84 | ACHE (0.59) | ACHEBCHEALDH1A1SMN1; SMN2 | |
| SCHEMBL12043451 | 0.83 | ACHE (0.55) | ACHEBCHELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010115124-A2 | COMPOSITIONS OF CHOLINESTERASE INHIBITORS | COLUCID PHARMACEUTICALS, INC. (US) | 2010-10-07 | — | — | WO | disclosed |