Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 8/20 | 0.67 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.61 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.58 |
| ▸ | IL2 | P60568 | 4/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907903 | 0.80 | KIT (0.70) | KITMAP3K11LRRK2DYRK1A | |
| SCHEMBL3769693 | 0.80 | KIT (0.69) | KITMAP3K11LRRK2MAP4K1IL2 | |
| SCHEMBL723899 | 0.79 | MAP3K11 (0.81) | KITMAP3K11LRRK2DYRK1A | |
| SCHEMBL21592999 | 0.79 | MAP4K1 (0.60) | KITMAP4K1IL2DYRK1A | |
| SCHEMBL721017 | 0.77 | MAP3K11 (1.00) | KITMAP3K11LRRK2DYRK1A | |
| SCHEMBL722944 | 0.77 | KIT (0.70) | KITMAP3K11LRRK2DYRK1A | |
| SCHEMBL22971774 | 0.76 | MAP4K1 (0.84) | MAP3K11LRRK2MAP4K1 | |
| SCHEMBL720896 | 0.76 | MAP3K11 (1.00) | KITMAP3K11LRRK2DYRK1A | |
| SCHEMBL31061059 | 0.75 | MAP3K11 (1.00) | KITMAP3K11LRRK2DYRK1A | |
| SCHEMBL722870 | 0.75 | MAP3K11 (1.00) | KITMAP3K11LRRK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |