Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 12/20 | 0.70 |
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.64 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903775 | 0.91 | KIT (0.73) | KITDYRK1APIK3CASLC2A1 | |
| SCHEMBL7899036 | 0.89 | KIT (0.63) | KITMAP3K11LRRK2DYRK1APIK3CA | |
| SCHEMBL7910174 | 0.86 | MAP3K11 (0.60) | KITMAP3K11DYRK1APIK3CASLC2A1 | |
| SCHEMBL3769693 | 0.85 | KIT (0.69) | KITMAP3K11LRRK2DYRK1APIK3CA | |
| SCHEMBL7910200 | 0.83 | KIT (0.58) | KITDYRK1APIK3CASLC2A1 | |
| SCHEMBL7905131 | 0.82 | MAP4K1 (0.54) | KITMAP3K11LRRK2 | |
| SCHEMBL12066048 | 0.82 | MAP4K1 (0.65) | KITMAP3K11LRRK2DYRK1A | |
| SCHEMBL7907491 | 0.82 | AXL (0.64) | KITMAP3K11 | |
| SCHEMBL7910407 | 0.81 | MAP3K11 (0.47) | KITMAP3K11DYRK1APIK3CA | |
| SCHEMBL7905041 | 0.81 | NTRK1 (0.63) | KITMAP3K11DYRK1APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |