Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18302831 | 0.82 | CYP19A1 (0.49) | CYP19A1TAAR1LMNACYP3A4TSHR | |
| SCHEMBL24286799 | 0.82 | CYP19A1 (0.49) | CYP19A1TAAR1LMNACYP3A4TSHR | |
| SCHEMBL20993237 | 0.82 | CYP19A1 (0.49) | CYP19A1TAAR1LMNACYP3A4TSHR | |
| SCHEMBL5725152 | 0.78 | TAAR1 (0.50) | CYP19A1TAAR1LMNACYP3A4TSHR | |
| SCHEMBL599776 | 0.77 | LMNA (0.46) | TAAR1LMNATSHRAKT1 | |
| SCHEMBL599240 | 0.77 | LMNA (0.46) | TAAR1LMNATSHRAKT1 | |
| SCHEMBL599775 | 0.77 | LMNA (0.46) | TAAR1LMNATSHRAKT1 | |
| SCHEMBL5112138 | 0.74 | CYP19A1 (0.47) | CYP19A1TAAR1LMNACYP3A4TSHR | |
| SCHEMBL30959376 | 0.73 | CYP19A1 (0.52) | CYP19A1TAAR1LMNACYP3A4TSHR | |
| SCHEMBL16397855 | 0.72 | TAAR1 (0.50) | CYP19A1TAAR1LMNATSHRFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616080-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | Gilead Sciences, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037038-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-22 | — | — | WO | disclosed |