Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646112 | 0.87 | POLB (0.50) | KMT2AALDH1A1POLBNOS1MAPT | |
| SCHEMBL7908694 | 0.80 | ALDH1A1 (0.53) | KMT2AALDH1A1POLBMAPTCYP19A1 | |
| SCHEMBL28748507 | 0.79 | ALDH1A1 (0.56) | KMT2AALDH1A1POLBMEN1HTT | |
| SCHEMBL27509144 | 0.79 | LMNA (0.54) | KMT2AALDH1A1POLBNOS1MAPT | |
| Bromide SCHEMBL29378435 | 0.78 | ALDH1A1 (0.54) | KMT2AALDH1A1POLBMEN1HTT | |
| SCHEMBL14720501 | 0.77 | ALDH1A1 (0.50) | KMT2AALDH1A1POLBMEN1NPSR1 | |
| SCHEMBL6115119 | 0.77 | ALDH1A1 (0.69) | KMT2AALDH1A1POLBLMNAHTT | |
| SCHEMBL7905621 | 0.76 | ALDH1A1 (0.49) | KMT2AALDH1A1POLBMAPTLMNA | |
| SCHEMBL5656670 | 0.76 | MAPT (0.50) | KMT2AALDH1A1POLBNOS1MAPT | |
| SCHEMBL3182549 | 0.76 | HTT (0.54) | KMT2AALDH1A1POLBNOS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197975-B1 | 7-AZABICYCLO(2.2.1)HEPTANE-7-CARBONYL-SUBSTITUTED 2-PHENYLINDOLE DERIVATIVES; SEXUAL DISORDERS; ANTICARCINOGENIC AGENTS | MERCK & CO. , INC. | 2001-03-06 | — | — | US | disclosed |
| CN-1209129-A | Antagonists of gonadotropin releasing hormone | MERCK & CO LTD (US) | 1999-02-24 | — | — | CN | disclosed |
| EP-0882040-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 1999-02-10 | — | — | EP | disclosed |
| EP-0882040-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997021707-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |