Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL601438 | 0.83 | — | — | |
| SCHEMBL4189879 | 0.80 | LMNA (0.47) | LMNATDP1CHRNB2CHRNA4CYP19A1 | |
| SCHEMBL4189876 | 0.80 | LMNA (0.47) | LMNATDP1CHRNB2CHRNA4CYP19A1 | |
| SCHEMBL29464820 | 0.75 | — | — | |
| SCHEMBL13665334 | 0.75 | — | — | |
| SCHEMBL7771216 | 0.75 | — | — | |
| SCHEMBL130691 | 0.75 | — | — | |
| SCHEMBL2539433 | 0.75 | — | — | |
| SCHEMBL13922667 | 0.74 | LMNA (0.46) | LMNATDP1CHRNB2CHRNA4CYP19A1 | |
| SCHEMBL5898125 | 0.73 | CA4 (0.43) | LMNACHRNB2CHRNA4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207676-B1 | Bicyclic amines | ZENECA LIMITED (GB) | 2001-03-27 | — | — | US | disclosed |