Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 11/20 | 0.47 |
| ▸ | SLK | Q9H2G2 | 11/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.44 |
| ▸ | TLK1 | Q9UKI8 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914160 | 0.80 | CXCR2 (0.43) | MEN1POLBKMT2AGSK3BPTPN5 | |
| SCHEMBL20057651 | 0.79 | KMT2A (0.79) | MEN1POLBKMT2A | |
| SCHEMBL7905830 | 0.79 | SIRT2 (0.48) | MEN1POLBKMT2AGSK3B | |
| SCHEMBL28884064 | 0.76 | HTR7 (0.55) | BRD4STK10SLKHTR7PTPRC | |
| SCHEMBL22171356 | 0.74 | STK10 (0.54) | BRD4STK10SLKGSK3BHTR7 | |
| SCHEMBL8067145 | 0.73 | HTR7 (0.55) | BRD4STK10SLKHTR7PTPRC | |
| SCHEMBL20057675 | 0.73 | MAPT (0.54) | POLBKMT2ASTK10SLKPTPN5 | |
| SCHEMBL7905940 | 0.72 | BRD4 (0.39) | MEN1POLBKMT2ABRD4 | |
| SCHEMBL29629017 | 0.72 | HTR7 (0.64) | HTR7PTPRCPTPN1PTPN5 | |
| SCHEMBL26556078 | 0.72 | HTR7 (0.64) | HTR7PTPRCPTPN1PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211220-B1 | ANTITUMOR AGENTS AND ANTICARCIINOGENIC AGENTS | CELL PATHWAYS, INC. | 2001-04-03 | — | — | US | disclosed |
| WO-1994029277-A1 | AMILINO- OR PYRIDYLAMINO- CYCLOBUTENE- 1,2-DIONE DERIVATIVES AS cGMP PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-22 | — | — | WO | disclosed |