Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913081 | 0.88 | HDAC3 (0.46) | MEN1KMT2APOLBHDAC3HDAC1 | |
| SCHEMBL7905834 | 0.84 | CXCR2 (0.45) | AKR1C3MAPTGAAKDM4ELMNA | |
| SCHEMBL17427536 | 0.84 | CXCR2 (0.52) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL7915476 | 0.83 | CNR1 (0.45) | MEN1KMT2APOLBHDAC3HDAC1 | |
| SCHEMBL7914160 | 0.82 | CXCR2 (0.43) | SIRT2SIRT1MEN1KMT2APOLB | |
| SCHEMBL7905484 | 0.82 | MEN1 (0.50) | MEN1KMT2AHDAC1EPHX2ALDH1A1 | |
| SCHEMBL7915451 | 0.82 | CNR1 (0.46) | MEN1KMT2APOLBCNR1 | |
| SCHEMBL7916081 | 0.81 | CNR1 (0.47) | PLK1CNR1 | |
| SCHEMBL7914175 | 0.79 | BUB1 (0.44) | MEN1KMT2APOLBHDAC3HDAC1 | |
| SCHEMBL7905946 | 0.79 | MEN1 (0.50) | MEN1KMT2APOLBGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211220-B1 | ANTITUMOR AGENTS AND ANTICARCIINOGENIC AGENTS | CELL PATHWAYS, INC. | 2001-04-03 | — | — | US | disclosed |
| WO-1994029277-A1 | AMILINO- OR PYRIDYLAMINO- CYCLOBUTENE- 1,2-DIONE DERIVATIVES AS cGMP PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-22 | — | — | WO | disclosed |