Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916375 | 0.82 | PDE4B (0.53) | PDE4DPDE4BPDE4APDE4CMAOA | |
| SCHEMBL8312871 | 0.80 | PDE4B (0.52) | PDE4DPDE4BPDE4APDE4CALDH1A1 | |
| SCHEMBL7906256 | 0.74 | PDE4B (0.53) | PDE4DPDE4BPDE4APDE4CALDH1A1 | |
| SCHEMBL7914465 | 0.73 | PDE4A (0.48) | PDE4DPDE4BPDE4APDE4CMAPK1 | |
| SCHEMBL7916424 | 0.71 | PDE4B (0.49) | PDE4DPDE4BPDE4APDE4CALDH1A1 | |
| SCHEMBL3548453 | 0.71 | PDE4A (0.72) | PDE4DPDE4BPDE4APDE4CALDH1A1 | |
| SCHEMBL6585357 | 0.71 | PDE4B (0.60) | PDE4DPDE4BPDE4ASIGMAR1PDE4C | |
| Daxalipram SCHEMBL450824 | 0.70 | PDE4B (1.00) | PDE4DPDE4BPDE4APDE4CHPGD | |
| Daxalipram SCHEMBL7760245 | 0.70 | PDE4B (1.00) | PDE4DPDE4BPDE4APDE4CHPGD | |
| Daxalipram SCHEMBL450823 | 0.70 | PDE4B (1.00) | PDE4DPDE4BPDE4APDE4CHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265402-B1 | ANTIINFLAMMATORY AGENTS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-07-24 | — | — | US | disclosed |
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |