Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.52 |
| ▸ | PDE4A | P27815 | 8/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CTSV | O60911 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916375 | 0.81 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL7906155 | 0.80 | PDE4D (0.53) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL7763026 | 0.77 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4CSIRT2 | |
| SCHEMBL7763030 | 0.77 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4CSIRT2 | |
| SCHEMBL7763023 | 0.77 | PDE4B (0.71) | PDE4BPDE4DPDE4APDE4CSIRT2 | |
| SCHEMBL7916424 | 0.74 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CKMT2A | |
| SCHEMBL7913451 | 0.74 | PDE4A (0.57) | PDE4BPDE4DPDE4APDE4CSIRT2 | |
| SCHEMBL7906256 | 0.72 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CKMT2A | |
| SCHEMBL6585357 | 0.69 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C | |
| Daxalipram SCHEMBL450824 | 0.69 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0924204-A1 | 2-PHENYLMORPHOLIN-5-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-06-23 | — | — | EP | disclosed |