Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 2/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13236099 | 0.80 | ALDH1A1 (0.35) | MALT1CYP2C19NCF1SLC2A1BRD4 | |
| SCHEMBL8954890 | 0.79 | MAPT (0.41) | MAPTHTTGAAALDH1A1KDM4E | |
| SCHEMBL10803538 | 0.78 | MAPT (0.69) | MALT1CYP2C19NCF1SLC2A1BRD4 | |
| SCHEMBL4974718 | 0.78 | IDO1 (0.47) | SLC2A1MAPTHTTGAA | |
| SCHEMBL24711106 | 0.77 | CYP2C19 (0.47) | MALT1CYP2C19NCF1SLC2A1BRD4 | |
| SCHEMBL30457115 | 0.77 | NCF1 (0.53) | MALT1CYP2C19NCF1SLC2A1BRD4 | |
| SCHEMBL15956333 | 0.77 | CYP2C19 (0.47) | MALT1CYP2C19NCF1SLC2A1BRD4 | |
| SCHEMBL28211899 | 0.77 | CYP2C19 (0.51) | MALT1CYP2C19NCF1SLC2A1BRD4 | |
| SCHEMBL4131272 | 0.77 | TAAR1 (0.48) | MALT1CYP2C19NCF1SLC2A1BRD4 | |
| SCHEMBL974274 | 0.77 | NCF1 (0.53) | MALT1CYP2C19NCF1SLC2A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343714-B1 | Phenylglycidate stereoisomers, conversion products thereof with e.g. 2-nitrothiophenol and preparation of diltiazem | DSM NV (NL) | 1994-11-02 | — | — | EP | claimed |
| EP-0343714-A1 | Phenylglycidate stereoisomers, conversion products thereof with e.g. 2-nitrothiophenol and preparation of diltiazem | DSM N.V. (NL) | 1989-11-29 | — | — | EP | claimed |
| JP-60116677-A | — | — | None | — | — | JP | disclosed |
| JP-60146884-A | — | — | None | — | — | JP | disclosed |
| JP-58194872-A | — | — | None | — | — | JP | disclosed |
| JP-61165363-A | — | — | None | — | — | JP | disclosed |
| JP-61165378-A | — | — | None | — | — | JP | disclosed |
| US-9388189-B2 | Pyrrolotriazinone derivatives as PI3K inhibitors | ALMIRALL, S.A. (ES) | 2016-07-12 | — | — | US | disclosed |
| US-20150291595-A1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | ALMIRALL, S.A. (ES) | 2015-10-15 | — | — | US | disclosed |
| EP-2909207-A1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | Almirall S.A. (ES) | 2015-08-26 | — | — | EP | disclosed |
| CN-104854108-A | Pyrrolotriazinone derivatives as pi3k inhibitors | ALMIRALL SA | 2015-08-19 | — | — | CN | disclosed |
| EP-0343714-B1 | Phenylglycidate stereoisomers, conversion products thereof with e.g. 2-nitrothiophenol and preparation of diltiazem | DSM NV (NL) | 1994-11-02 | — | — | EP | disclosed |
| EP-0343714-A1 | Phenylglycidate stereoisomers, conversion products thereof with e.g. 2-nitrothiophenol and preparation of diltiazem | DSM N.V. (NL) | 1989-11-29 | — | — | EP | disclosed |
| US-4654335-A | CARDIOVASCULAR AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0208964-A2 | 1,5-Benzothiazepine compounds | E.R. Squibb & Sons, Inc. (US) | 1987-01-21 | — | — | EP | disclosed |
| JP-S61165378-A | PRODUCTION OF BENZOTHIAZEPINE DERIVATIVE | FUJITA HARUSHIGE | 1986-07-26 | — | — | JP | disclosed |
| JP-S61165363-A | CINNAMIC ACID AMIDE DERIVATIVE AND PRODUCTION THEREOF | FUJITA HARUSHIGE | 1986-07-26 | — | — | JP | disclosed |
| JP-S60146884-A | PRODUCTION OF 1,5-BENZOTHIAZEPINE DERIVATIVE | NIPPON CHEM:KK | 1985-08-02 | — | — | JP | disclosed |
| JP-S60116677-A | PRODUCTION OF BENZOTHIAZEPINE DERIVATIVE | FUJITA HARUSHIGE | 1985-06-24 | — | — | JP | disclosed |
| JP-S58194872-A | PREPARATION OF BENZOTHIAZEPINE DERIVATIVE | TOKAWA TETSUO | 1983-11-12 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291595-A1 | PYRROLOTRIAZINONE DERIVATIVES AS PI3K INHIBITORS | PIK3CB, PIK3CD, PIK3CA | MALT1 1020/4885CYP2C19 802/4885NCF1 1230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.