Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690481 | 0.91 | ADRB1 (0.48) | OPRM1OPRD1OPRK1OPRL1ADRB2 | |
| SCHEMBL13849942 | 0.91 | ADRB1 (0.48) | OPRM1OPRD1OPRK1OPRL1ADRB2 | |
| SCHEMBL13849930 | 0.91 | ADRB1 (0.48) | OPRM1OPRD1OPRK1OPRL1ADRB2 | |
| SCHEMBL14402491 | 0.91 | ADRB1 (0.48) | OPRM1OPRD1OPRK1OPRL1ADRB2 | |
| SCHEMBL4773480 | 0.86 | KMT2A (0.52) | ADRB2ADRB1ADRB3SLC2A1EPHX2 | |
| SCHEMBL18548557 | 0.85 | ADRB3 (0.46) | ADRB2ADRB1ADRB3SLC2A1IDO1 | |
| SCHEMBL29493206 | 0.85 | ADRB3 (0.46) | ADRB2ADRB1ADRB3SLC2A1IDO1 | |
| SCHEMBL14733313 | 0.85 | KCNH2 (0.44) | OPRM1OPRD1OPRK1OPRL1ADRB2 | |
| Hydrochloric Acid SCHEMBL4716146 | 0.85 | KMT2A (0.51) | ADRB2ADRB1ADRB3SLC2A1EPHX2 | |
| SCHEMBL27173375 | 0.85 | OPRM1 (0.46) | OPRM1OPRD1OPRK1OPRL1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |
| WO-1998050031-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |