Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4992458 | 0.78 | GAA (0.80) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL25409408 | 0.78 | GAA (0.80) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL5804993 | 0.78 | GAA (0.80) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL8152205 | 0.78 | GAA (0.51) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL8728663 | 0.76 | GAA (0.67) | GAANPY5RALDH1A1KDM4EMEN1 | |
| SCHEMBL8728560 | 0.76 | GAA (0.67) | GAANPY5RALDH1A1KDM4EMEN1 | |
| SCHEMBL16147201 | 0.76 | GAA (0.67) | GAANPY5RALDH1A1KDM4EMEN1 | |
| SCHEMBL6908215 | 0.75 | GAA (0.74) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL3447213 | 0.75 | GAA (0.74) | GAANPY5RALDH1A1KDM4EAOC3 | |
| SCHEMBL6223855 | 0.75 | GAA (0.74) | GAANPY5RALDH1A1KDM4EAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |