Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 13/20 | 0.47 |
| ▸ | PPARA | Q07869 | 12/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907641 | 0.89 | PPARG (0.46) | PPARGPPARARXFP1FFAR1PPARD | |
| SCHEMBL5856859 | 0.83 | PPARG (0.55) | PPARGPPARARXFP1PPARDKDM4E | |
| SCHEMBL5855420 | 0.81 | PPARG (0.56) | PPARGPPARARXFP1PPARDKDM4E | |
| SCHEMBL6511253 | 0.81 | KDM4E (0.60) | PPARGPPARAKDM4ERAB9AKMT2A | |
| SCHEMBL5857599 | 0.80 | PPARG (0.62) | PPARGPPARAPPARDKDM4ERAB9A | |
| SCHEMBL6962848 | 0.80 | FFAR1 (0.71) | PPARGPPARAFFAR1PPARDKDR | |
| SCHEMBL4925692 | 0.79 | TP53 (0.52) | RXFP1KDM4ERAB9ANPC1KMT2A | |
| SCHEMBL19697550 | 0.78 | KDR (0.50) | PPARGPPARARXFP1FFAR1KDM4E | |
| SCHEMBL5858351 | 0.78 | PPARG (0.60) | PPARGPPARAPPARDKDM4ERAB9A | |
| SCHEMBL5368869 | 0.77 | KDM4E (0.47) | PPARGPPARARXFP1FFAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083888-A1 | MULTIBINDING AGENTS THAT MODULATE PPARgamma AND RXR RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063983-A9 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999063983-A1 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |