Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365528 | 0.88 | KDM4E (0.57) | KDM4ERAB9APOLBMAPTSMN1; SMN2 | |
| SCHEMBL4925692 | 0.85 | TP53 (0.52) | KDM4ERAB9APOLBSMN1; SMN2KMT2A | |
| SCHEMBL19697550 | 0.84 | KDR (0.50) | KDM4ERAB9APOLBMAPTPPARG | |
| SCHEMBL4359109 | 0.84 | KDM4E (0.56) | KDM4ERAB9APOLBMAPTSMN1; SMN2 | |
| SCHEMBL5762006 | 0.82 | HSD17B10 (0.56) | KDM4EPOLBMAPTSMN1; SMN2PPARA | |
| SCHEMBL5093853 | 0.82 | TARBP2 (0.54) | KDM4ERAB9APOLBSMN1; SMN2PPARG | |
| SCHEMBL5096428 | 0.82 | ALDH1A1 (0.51) | KDM4ERAB9APOLBMAPTSMN1; SMN2 | |
| SCHEMBL4037331 | 0.81 | KDM4E (0.69) | KDM4ERAB9APPARGPPARATP53 | |
| SCHEMBL7906342 | 0.81 | PPARG (0.47) | KDM4ERAB9APPARGPPARAKMT2A | |
| SCHEMBL5385072 | 0.80 | KDM4E (0.50) | KDM4ERAB9AMAPTPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355686-A1 | NOVEL OXAZOLE COMPOUNDS AS BETA CATENIN MODULATORS AND USES THEREOF | UNIV NEW YORK (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355686-A1 | NOVEL OXAZOLE COMPOUNDS AS BETA CATENIN MODULATORS AND USES THEREOF | UNIV NEW YORK (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355686-A1 | NOVEL OXAZOLE COMPOUNDS AS BETA CATENIN MODULATORS AND USES THEREOF | UNIV NEW YORK (US) | 2017-12-14 | — | — | US | disclosed |
| EP-3220915-A1 | NOVEL OXAZOLE COMPOUNDS AS -CATENIN MODULATORS AND USES THEREOF | New York University (US) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016081451-A1 | NOVEL OXAZOLE COMPOUNDS AS β-CATENIN MODULATORS AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2016-05-26 | — | — | WO | disclosed |
| WO-2016081451-A1 | NOVEL OXAZOLE COMPOUNDS AS β-CATENIN MODULATORS AND USES THEREOF | NEW YORK UNIVERSITY (US) | 2016-05-26 | — | — | WO | disclosed |
| WO-2005040127-A1 | NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | LG LIFE SCIENCES LTD. (KR) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355686-A1 | NOVEL OXAZOLE COMPOUNDS AS BETA CATENIN MODULATORS AND USES THEREOF | CTNNB1, CTNND1, CTNNA1 | KDM4E 3770/4885RAB9A 2586/4885POLB 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.