Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.46 |
| ▸ | PPARA | Q07869 | 11/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906342 | 0.89 | PPARG (0.47) | PPARGPPARAKMT2ARXFP1FFAR1 | |
| SCHEMBL7908153 | 0.82 | PPARA (0.50) | PPARGPPARAPPARD | |
| SCHEMBL4826525 | 0.82 | KDM4E (0.45) | PPARGPPARARXFP1FFAR1PPARD | |
| SCHEMBL5856859 | 0.81 | PPARG (0.55) | PPARGPPARARXFP1PPARDRAB9A | |
| SCHEMBL5855420 | 0.79 | PPARG (0.56) | PPARGPPARARXFP1PPARDRAB9A | |
| SCHEMBL4359109 | 0.79 | KDM4E (0.56) | PPARGPPARAKMT2ARAB9AKDM4E | |
| SCHEMBL5857599 | 0.78 | PPARG (0.62) | PPARGPPARAPPARDRAB9AKDM4E | |
| SCHEMBL15782237 | 0.77 | KDM4E (0.43) | KMT2ARXFP1FFAR1RAB9AKDM4E | |
| SCHEMBL6962848 | 0.77 | FFAR1 (0.71) | PPARGPPARAFFAR1PPARD | |
| SCHEMBL2330165 | 0.77 | TP53 (0.49) | KMT2ARXFP1RAB9AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083888-A1 | MULTIBINDING AGENTS THAT MODULATE PPARgamma AND RXR RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063983-A9 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999063983-A1 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |