Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6320475 | 0.80 | LMNA (0.48) | LMNAGAATRPV4CYP2D6CYP3A4 | |
| SCHEMBL18391573 | 0.80 | LMNA (0.48) | LMNAGAATRPV4EPHX2HRH3 | |
| SCHEMBL12205468 | 0.78 | POLB (0.50) | LMNAGAATRPV4TSHRKDM4E | |
| SCHEMBL3245210 | 0.78 | LMNA (0.47) | LMNAGAATRPV4EPHX2HRH3 | |
| SCHEMBL26203636 | 0.78 | LMNA (0.47) | LMNAGAATRPV4EPHX2HRH3 | |
| SCHEMBL20094603 | 0.78 | LMNA (0.43) | LMNAGAATRPV4EPHX2HRH3 | |
| SCHEMBL22003894 | 0.78 | — | — | |
| SCHEMBL2261416 | 0.78 | POLB (0.42) | GAATSHR | |
| SCHEMBL18705057 | 0.76 | POLB (0.61) | LMNAGAACYP2D6TSHRCYP3A4 | |
| SCHEMBL14883722 | 0.75 | LMNA (0.44) | LMNAGAATRPV4EPHX2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194438-B1 | ANTITUMOR AGENTS; ANTICANCER AGENTS; FARNESYL-PROTEIN TRANSFERASE INHIBITOR | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1006113-A1 | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth | Pfizer Products Inc. (US) | 2000-06-07 | — | — | EP | disclosed |