Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19066410 | 0.80 | LMNA (0.33) | LMNAGAAPOLBNPSR1L3MBTL1 | |
| SCHEMBL1746338 | 0.79 | — | — | |
| SCHEMBL973439 | 0.79 | POLB (0.40) | GAAALDH1A1POLBL3MBTL1TSHR | |
| SCHEMBL28361930 | 0.79 | KDM4E (0.38) | LMNAGAAKDM4EALDH1A1MAPT | |
| SCHEMBL7906446 | 0.78 | LMNA (0.48) | LMNAGAATRPV4EPHX2CHRNA7 | |
| SCHEMBL6320475 | 0.78 | LMNA (0.48) | LMNAGAATRPV4KDM4EALDH1A1 | |
| SCHEMBL18391573 | 0.78 | LMNA (0.48) | LMNAGAATRPV4EPHX2CHRNA7 | |
| SCHEMBL26203636 | 0.76 | LMNA (0.47) | LMNAGAATRPV4EPHX2CHRNA7 | |
| SCHEMBL12205468 | 0.76 | POLB (0.50) | LMNAGAATRPV4KDM4EALDH1A1 | |
| SCHEMBL8659738 | 0.76 | KDM4E (0.42) | LMNAGAAKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233947-B2 | Sulfamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2016-01-12 | — | — | US | disclosed |
| US-20140243329-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-08-28 | — | — | US | disclosed |
| US-8748478-B2 | Sulfamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-06-10 | — | — | US | disclosed |
| EP-2379521-B1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-22 | — | — | EP | disclosed |
| US-20130237547-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-09-12 | — | — | US | disclosed |
| US-8436041-B2 | Sulfamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-07 | — | — | US | disclosed |
| WO-2010080397-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-15 | — | — | WO | disclosed |
| US-20100160337-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130237547-A1 | SULFAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | LMNA 4330/4885GAA 2702/4885TRPV4 12/4885 |
| US-20100160337-A1 | SULFAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | LMNA 4330/4885GAA 2702/4885TRPV4 12/4885 |
| US-20140243329-A1 | SULFAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | LMNA 4330/4885GAA 2702/4885TRPV4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.