Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.58 |
| ▸ | CCR8 | P51685 | 1/20 | 0.58 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 14/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23888704 | 0.79 | CCR1 (0.52) | CCR1CCR8NOS3NOS2TGFBR1 | |
| SCHEMBL7910798 | 0.79 | KDM4E (0.46) | CCR1CCR8TGFBR1 | |
| SCHEMBL3723641 | 0.76 | CCR1 (0.58) | CCR1CCR8NOS3NOS2TGFBR1 | |
| SCHEMBL7911485 | 0.76 | CDK2 (0.41) | NOS3NOS2TGFBR1 | |
| SCHEMBL8101860 | 0.76 | CCR1 (0.52) | CCR1CCR8NOS3NOS2TGFBR1 | |
| SCHEMBL995546 | 0.76 | CCR1 (0.52) | CCR1CCR8NOS3NOS2TGFBR1 | |
| SCHEMBL30511194 | 0.75 | CCR1 (1.00) | CCR1CCR8NOS3NOS2TGFBR1 | |
| SCHEMBL196966 | 0.75 | CCR1 (1.00) | CCR1CCR8NOS3NOS2TGFBR1 | |
| SCHEMBL29388304 | 0.75 | CCR1 (1.00) | CCR1CCR8NOS3NOS2TGFBR1 | |
| SCHEMBL5687521 | 0.74 | CCR1 (0.50) | CCR1CCR8NOS3NOS2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063663-A1 | N-{[(IR,4S,6R-3-(2-PYRIDINYLCARBONYL)-3-AZABICYCLO [4.1.0]HEPT-4-YL] METHYL}-2-HETEROARYLAMINE DERIVATIVES AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2010-06-10 | — | — | WO | disclosed |