Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CCR1 | P32246 | 2/20 | 0.45 |
| ▸ | CCR5 | P51681 | 2/20 | 0.45 |
| ▸ | CCR8 | P51685 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10262377 | 0.81 | KDM4E (0.48) | KDM4ESMN1; SMN2TP53NPC1L3MBTL1 | |
| SCHEMBL798061 | 0.81 | KDM4E (0.50) | KDM4ESMN1; SMN2TP53NPC1L3MBTL1 | |
| SCHEMBL13637232 | 0.79 | NOS3 (0.42) | KDM4ESMN1; SMN2TP53NPC1L3MBTL1 | |
| SCHEMBL7907148 | 0.79 | CCR1 (0.58) | TGFBR1CCR1CCR8 | |
| SCHEMBL29930798 | 0.79 | NPC1 (0.41) | KDM4ESMN1; SMN2TP53NPC1L3MBTL1 | |
| SCHEMBL30496476 | 0.78 | TGFBR1 (0.43) | KDM4ESMN1; SMN2TP53NPC1L3MBTL1 | |
| SCHEMBL7915364 | 0.77 | MBOAT4 (0.47) | KDM4ENPC1RAB9ACYP1A2HTT | |
| SCHEMBL16876610 | 0.77 | TDO2 (0.47) | KDM4ESMN1; SMN2TP53NPC1L3MBTL1 | |
| SCHEMBL30761191 | 0.76 | IKBKB (0.49) | KDM4ESMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL16129055 | 0.75 | KDM4E (0.51) | KDM4ESMN1; SMN2TP53NPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063663-A1 | N-{[(IR,4S,6R-3-(2-PYRIDINYLCARBONYL)-3-AZABICYCLO [4.1.0]HEPT-4-YL] METHYL}-2-HETEROARYLAMINE DERIVATIVES AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2010-06-10 | — | — | WO | disclosed |