SCHEMBL7907176

SCHEMBL7907176

O=C(CCCc1ccc(OCc2ccccc2)cc1)OCc1ccccc1

nearest known ligand 0.66

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 8/20 0.66
FFAR4 Q5NUL3 3/20 0.66
LTA4H P09960 1/20 0.63
EPHX2 P34913 1/20 0.63
ALOX5 P09917 2/20 0.56
NR4A1 P22736 1/20 0.54
NR4A2 P43354 1/20 0.54
NR4A3 Q92570 1/20 0.54
BCHE P06276 2/20 0.54
MGLL Q99685 2/20 0.53
AKR1B1 P15121 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7276062 0.91 FFAR1 (0.74) FFAR1FFAR4LTA4HEPHX2ALOX5
SCHEMBL19825762 0.90 FFAR1 (0.61) FFAR1FFAR4LTA4HEPHX2ALOX5
SCHEMBL14368556 0.89 TDP1 (0.61) ALOX5MGLL
SCHEMBL31329294 0.87 ALDH1A1 (0.61) FFAR1ALOX5
SCHEMBL1860911 0.87 FFAR1 (0.64) FFAR1FFAR4LTA4HEPHX2ALOX5
SCHEMBL7905578 0.86 FFAR1 (0.82) FFAR1FFAR4LTA4HEPHX2ALOX5
SCHEMBL14793821 0.86 TRPV1 (0.57) ALOX5MGLLAKR1B1
SCHEMBL8890454 0.86 FFAR1 (0.59) FFAR1FFAR4LTA4HEPHX2ALOX5
SCHEMBL8350924 0.86 CYP4F2 (0.60) FFAR1FFAR4NR4A2BCHEMGLL
SCHEMBL8888760 0.85 FFAR1 (0.58) FFAR1FFAR4LTA4HEPHX2ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6197975-B1 7-AZABICYCLO(2.2.1)HEPTANE-7-CARBONYL-SUBSTITUTED 2-PHENYLINDOLE DERIVATIVES; SEXUAL DISORDERS; ANTICARCINOGENIC AGENTS MERCK & CO. , INC. 2001-03-06 US disclosed
EP-0868178-A4 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO INC (US) 2000-03-29 EP disclosed
EP-0882040-A4 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO INC (US) 1999-02-10 EP disclosed
EP-0882040-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE Merck & Co., Inc. (US) 1998-12-09 EP disclosed
EP-0868178-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE Merck & Co., Inc. (US) 1998-10-07 EP disclosed
US-5756507-A TREATING SEX HORMONE RELATED DISORDERS MERCK & CO., INC. (US) 1998-05-26 US disclosed
WO-1997021707-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1997-06-19 WO disclosed
WO-1997021435-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1997-06-19 WO disclosed