Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728287 | 0.94 | MAPT (0.41) | MAPTALDH1A1GAACA1CA2 | |
| SCHEMBL1414807 | 0.85 | MAPT (0.52) | MAPTALDH1A1GAACA1CA2 | |
| SCHEMBL12237514 | 0.79 | GAA (0.62) | MAPTALDH1A1GAACA1CA2 | |
| SCHEMBL7908264 | 0.79 | ALDH1A1 (0.35) | MAPTALDH1A1GAAKMT2ARAB9A | |
| SCHEMBL8723108 | 0.76 | ALDH1A1 (0.35) | MAPTALDH1A1GAAKMT2ARAB9A | |
| SCHEMBL243401 | 0.76 | CYP17A1 (0.56) | MAPTALDH1A1CA1CA2CA12 | |
| SCHEMBL4749029 | 0.76 | MAPT (0.55) | MAPTALDH1A1GAACA1CA2 | |
| SCHEMBL8385553 | 0.74 | MAPT (0.48) | MAPTALDH1A1CA2CA12EPHX2 | |
| SCHEMBL617014 | 0.73 | MAPT (0.52) | MAPTALDH1A1CA1CA2EPHX2 | |
| SCHEMBL4884888 | 0.72 | GAA (0.44) | MAPTALDH1A1GAACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6217845-B1 | IMAGING; THERAPY | ANORMED, INC. (CA) | 2001-04-17 | — | — | US | disclosed |
| EP-0384769-B1 | Protein labelling | JOHNSON MATTHEY PLC (GB) | 1996-04-24 | — | — | EP | disclosed |
| US-5420285-A | Imaging for medicine | JOHNSON MATTHEY, INC. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0384769-A2 | Protein labelling | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 1990-08-29 | — | — | EP | disclosed |