SCHEMBL7907463

SCHEMBL7907463

CC(C)COc1cc(OCc2ccccc2)ccc1C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.57
MCL1 Q07820 2/20 0.51
ADRB3 P13945 3/20 0.50
NR4A2 P43354 2/20 0.50
ADRB1 P08588 2/20 0.50
NR4A1 P22736 1/20 0.50
NR4A3 Q92570 1/20 0.50
LTB4R Q15722 1/20 0.50
LTB4R2 Q9NPC1 1/20 0.50
ABCB1 P08183 1/20 0.49
SLC16A3 O15427 1/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
ALDH1A1 P00352 1/20 0.48
HPGD P15428 1/20 0.48
MDH2 P40926 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7908707 0.95 MCL1 (0.54) MAOBMCL1ADRB3NR4A2ADRB1
SCHEMBL4277112 0.88 MAOB (0.53) MAOBMCL1ABCB1MEN1KMT2A
SCHEMBL4756552 0.87 MAOB (0.63) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL712875 0.86 MAOB (0.60) MAOBMCL1ADRB3NR4A2ADRB1
SCHEMBL14021709 0.86 MAOB (0.53) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL1448026 0.85 MAOB (0.61) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL21924233 0.84 MAOB (0.60) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL7908648 0.84 RXRA (0.61) MAOBMCL1LTB4RLTB4R2
SCHEMBL11283190 0.83 MAOB (0.59) MAOBMCL1NR4A2NR4A1NR4A3
SCHEMBL7908997 0.83 MAOB (0.53) MAOBMCL1NR4A2NR4A1NR4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211234-B1 BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID RHONE-POULENC RORER LIMITED (GB) 2001-04-03 US disclosed
EP-0728128-B1 SUBSTITUTED PHENYL COMPOUNDS RHONE POULENC RORER LTD (GB) 1998-09-16 EP disclosed
EP-0728128-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1996-08-28 EP disclosed
WO-1995013262-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1995-05-18 WO disclosed