Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.61 |
| ▸ | RXRB | P28702 | 1/20 | 0.61 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | BCL2 | P10415 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6391576 | 0.89 | MCL1 (0.56) | RXRARXRBMRGPRX4MCL1MAOB | |
| SCHEMBL7910727 | 0.89 | RXRA (0.54) | RXRARXRBMRGPRX4MCL1MAOB | |
| SCHEMBL4756552 | 0.88 | MAOB (0.63) | MCL1MAOBKDM4EFOLH1ALOX5 | |
| SCHEMBL7900610 | 0.85 | RAB9A (0.58) | RXRAMRGPRX4MCL1MAOBKDM4E | |
| SCHEMBL7908820 | 0.85 | NR4A2 (0.60) | RXRARXRBMRGPRX4MCL1MAOB | |
| SCHEMBL7907913 | 0.85 | NR4A2 (0.60) | RXRARXRBMRGPRX4MCL1MAOB | |
| SCHEMBL128622 | 0.85 | RXRA (0.57) | RXRARXRBMRGPRX4KDM4EFOLH1 | |
| SCHEMBL7901056 | 0.84 | MRGPRX4 (0.61) | MRGPRX4MCL1MAOBNPC1RAB9A | |
| SCHEMBL7908707 | 0.84 | MCL1 (0.54) | MCL1MAOBFOLH1LTB4RLTB4R2 | |
| SCHEMBL712875 | 0.84 | MAOB (0.60) | MCL1MAOBLTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211234-B1 | BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID | RHONE-POULENC RORER LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-0728128-B1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE POULENC RORER LTD (GB) | 1998-09-16 | — | — | EP | disclosed |
| EP-0728128-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013262-A1 | SUBSTITUTED PHENYL COMPOUNDS | RHONE-POULENC RORER LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |