Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905360 | 0.86 | PTPN11 (0.46) | PTPN11PIK3CDCA1CA2L3MBTL1 | |
| SCHEMBL7907052 | 0.83 | PTPN11 (0.46) | PTPN11PIK3CDCA1CA2L3MBTL1 | |
| SCHEMBL12066674 | 0.80 | PTPN11 (0.49) | PTPN11PIK3CDL3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL7907976 | 0.79 | PTPN11 (0.50) | PTPN11PIK3CDL3MBTL1CYP11B1CYP11B2 | |
| SCHEMBL720829 | 0.79 | TGFBR1 (0.41) | PTPN11CA1CA2L3MBTL1MEN1 | |
| SCHEMBL28706993 | 0.78 | PTPN11 (0.41) | PTPN11CA1CA2L3MBTL1MEN1 | |
| SCHEMBL12066665 | 0.77 | MAP3K11 (0.47) | PTPN11PIK3CDIDO1IKBKBCHUK | |
| SCHEMBL28712257 | 0.77 | L3MBTL1 (0.42) | PTPN11CA1CA2L3MBTL1MEN1 | |
| SCHEMBL12066045 | 0.76 | PTPN11 (0.47) | PTPN11BRD4 | |
| SCHEMBL30641868 | 0.76 | L3MBTL1 (0.39) | PTPN11L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |